Positions

Postdoctoral positions in imaging and neurobiology

The University Medical Center Göttingen is an important healthcare center and offers great development potential. Its 7,900 employees work in over 65 departments and facilities, to provide top-quality patient care, excellent research and modern teaching. Göttingen, renowned as the “City of Science”, is located near the center of Germany, and hosts an impressive number of private and academic research institutions, in which the Medical Center is strongly embedded.

The candidates will join the Institute of Neuro- and Sensory Physiology, led by Prof. Dr. Silvio Rizzoli. The Institute combines multiple advanced imaging tools to analyze neuronal and synaptic structure and function. In the last few years, the institute has characterized the molecular organization of the synapse by integrating stimulated emission depletion (STED) microscopy with electron microscopy and quantitative biochemistry (Wilhelm et al., Science, 2014), has introduced new methods to analyze the long-term dynamics of synaptic organelles (Truckenbrodt et al., EMBO J, 2018), and has developed tools for the analysis of protein lifetimes in vivo (Fornasiero et al., Nat Comm, 2018; Alevra et al., Nat Protocols, 2019). Biological investigations are supported by technology development works, ranging from improvements in sample preparation (Richter et al., EMBO J, 2018) to imaging probe development (Vreja et al., Angew Chem Int Ed Engl, 2015; Kabatas et al., Angew Chem Int Ed Engl, 2019).

The current projects, which are supported by several recently acquired third-party grants, focus on the following:

    • The development of imaging techniques based on X10 expansion microscopy, recently developed in the institute (Truckenbrodt et al., EMBO Rep, 2018; Truckenbrodt et al., Nat Protocols, 2019), in combination with small affinity probes and novel imaging assays (for example Gerdes et al., Nat Comm, 2020). These technologies will be applied to investigate synaptic structure and long-term dynamics.
    • The development and application of secondary ion mass spectrometry (SIMS) imaging tools, for the investigation of the turnover of proteins, lipids, sugars and nucleic acids in vitro and in vivo, from cell cultures to humans. The work will be based especially on nanoSIMS and imaging developments (see for example Saka et al., Nat Comm, 2014; Saal et al., ACS Nano, 2018).

Our institute, including the groups of Silvio Rizzoli (synaptic function and super-resolution imaging), Felipe Opazo (probe development) and Eugenio Fornasiero (neuronal biology and turnover), has an international and interdisciplinary team of PhD students and postdoctoral researchers. Our everyday language is English. The institute is part of several excellence networks, and has active collaborations on five continents.

The candidates will participate in the design and the implementation of the tools indicates above, within the framework of the institute’s research. They will also have the opportunity to refine their management skills by the design and supervision of student research projects (BSc and MSc), and will benefit from a broad variety of advanced training opportunities, including courses on key academic skills, networking, coaching and consultation.

The positions are available from 01.11.2020 on a full time basis, for an initial 2.5 years, with the possibility of prolongation. The salary is based on remuneration group 13 TV-L of the pay scale for the German public sector.

 

Your profile

We are looking for highly motivated and science-driven candidates with a strong interest in imaging and technical development. The ideal candidates obtained their doctoral degrees in the areas of neurobiology, biochemistry, optical imaging or SIMS within the last three years, or will obtain the degree in the next few months. They need to have a solid publication record, with at least one first-author publication in a well-known peer-reviewed journal. Familiarity with quantitative image analysis and software programming is desirable.

Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment. We look forward to receiving your application by August 31st, 2020.

Applications containing a cover letter explaining the relevant work experience, the CV, copies of final university certificates and the contact details of two referees should be sent to:

silvio.rizzoli@… in a single PDF file (subject: Imaging&Neurobiology).