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Mitochondria- and metabolism-derived signaling are equally important for the dynamic We analyze such mitochondria- and metabolism derived signaling in functionally <\/p>\n Research Interests<\/span> Tel. +49-551-39 65 909 Mitochondria- and metabolism-derived signaling are equally important for the dynamic responsiveness of neuronal networks, synaptic plasticity and single-cell function. Disturbed signaling and mitochondrial dysfunction are considered as the underlying causes of a variety of neurodevelopmental and neurodegenerative diseases. We analyze such mitochondria- and metabolism derived signaling in functionally intact hippocampal\/medullary preparations of rats and … <\/p>\n
\nresponsiveness of neuronal networks, synaptic plasticity and single-cell function.
\nDisturbed signaling and mitochondrial dysfunction are considered as the underlying causes
\nof a variety of neurodevelopmental and neurodegenerative diseases.<\/span><\/span><\/p>\n
\nintact hippocampal\/medullary preparations of rats and mice by combining classic
\nelectrophysiological approaches with high-resolution and multiphoton microscopy and the
\nuse of advanced optical sensors.<\/span><\/span><\/p>\n
\n\u2014 Intracellular strategic positioning and functional heterogeneity of mitochondria<\/span>
\n\u2014 Modulation of organelle interactions via mitochondria-derived signaling (ROS, NOS, Ca2+<\/sup>, ATP)<\/span>
\n\u2014 Intracellular signaling function of ROS and redox changes in complex neuronal networks<\/span>
\n\u2014 Defined redox modulation of cellular proteins (ion channels, receptors, regulatory<\/span>
\nand structural proteins) by changes in mitochondrial metabolism<\/span>
\n\u2014 Mitochondrial dysfunction and redox imbalance in Rett syndrome<\/span>
\n\u2014 Responses of complex neuronal networks to metabolic compromise<\/span><\/p>\n
\nGroup Members<\/span><\/span>
\nProf. Dr. Michael M\u00fcller, Group Leader<\/a>
\nM.Sc. Gocha Golubiani, PhD Student<\/a>
\nM.Sc. Laura van Agen, PhD Student<\/a>
\nMoritz Kirschner, MD Student<\/a><\/span><\/span><\/p>\n
\nDeutsch ![\"\"](\"https:\/\/www.neuro-physiol.med.uni-goettingen.de\/wordpress\/wp-content\/uploads\/Pfeil-rechts.png\")
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\n mmuelle7(at)\u2026<\/a>
\nwwwuser.gwdg.de\/~mmuelle7\/<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"