The diffraction barrier has been particularly problematic for imaging synaptic vesicles, which are
among the smallest known organelles (30–50nm diameter). They are located in small areas in
the synapses (about 1µm in diameter).
Our group takes advantage of increase imaging resolution provided by different types of
microscopy to investigate synaptic vesicle function, with an emphasis on synaptic vesicle recycling.
Since STED microscopy also allows imaging of protein domains, the group aims at studying the
patterning of protein domains in the synapse, in order to understand its molecular architecture.
Tel. +49-551-39 65 911
srizzol(at)…
rizzoli-lab.de