Mitochondria- and metabolism-derived signaling are equally important for the dynamic
responsiveness of neuronal networks, synaptic plasticity and single-cell function.
Disturbed signaling and mitochondrial dysfunction are considered as the underlying causes
of a variety of neurodevelopmental and neurodegenerative diseases.
We analyze such mitochondria- and metabolism derived signaling in functionally
intact hippocampal/medullary preparations of rats and mice by combining classic
electrophysiological approaches with high-resolution and multiphoton microscopy and the
use of advanced optical sensors.
Research Interests
— Intracellular strategic positioning and functional heterogeneity of mitochondria
— Modulation of organelle interactions via mitochondria-derived signaling (ROS, NOS, Ca2+, ATP)
— Intracellular signaling function of ROS and redox changes in complex neuronal networks
— Defined redox modulation of cellular proteins (ion channels, receptors, regulatory
and structural proteins) by changes in mitochondrial metabolism
— Mitochondrial dysfunction and redox imbalance in Rett syndrome
— Responses of complex neuronal networks to metabolic compromise
Group Members
Prof. Dr. Michael Müller, Group Leader
M.Sc. Gocha Golubiani, PhD Student
Moritz Kirschner, MD Student
Tel. +49-551-39 65 909
mmuelle7(at)…
wwwuser.gwdg.de/~mmuelle7/